Tuesday, July 8, 2025
Germany Latest News
  • Sports
  • USA
  • Asia
  • Health
  • Life Style
  • Tech
  • Science
  • Latin America
  • Africa
  • Europe
No Result
View All Result
Germany Latest News

A tiny crater on viruses behind the common cold may be their Achilles heel

by The Editor
June 12, 2019
in Science
0
A tiny crater on viruses behind the common cold may be their Achilles heel

A newly discovered indentation on the surface of viruses that cause many illnesses, including the common cold, could be their Achilles heel — and a possible target for effective drugs.

When scientists tested antiviral compounds on cells grown in the lab, the team found one that blocked the replication of an enterovirus. Cryo-electron microscopy revealed that the compound binds to and appears to jam a previously unknown pocket on the viruss protein shell, researchers report online June 11 in PLOS Biology.

Additional testing suggests that the pocket is widespread among picornaviruses, the viral family that includes enteroviruses — which cause hand, foot and mouth disease as well as more dangerous infections — and rhinoviruses, responsible for the common cold. There are no antiviral medications available to treat these pathogens.

The pocket “is an excellent target for antivirals” that may be effective against many of these types of viruses, says Susan Hafenstein, a structural virologist with the College of Medicine at Penn State who was not involved in the study.

These viruses mutate very frequently, which makes it “easier for them to escape a drug,” she says. To identify drug targets in the viruses, “it is essential to identify key working components” that these pathogens need to survive.

During an infection, viruses inject their genetic material into cells and take over the cellular machinery to make more viral particles. In picornaviruses, a protein shell surrounds the viruss inner core of genetic material. Previous research suggests the shell changes shape when these viruses are ready to expel their genetic payload during an infection.

But a chemical compound, identified by structural virologist Sarah Butcher of the University of Helsinki, virologist Johan Neyts of the University of Leuven in Belgium andRead More – Source

science news

Related posts

Can Misinfo Harm Science?

Can Misinfo Harm Science?

February 7, 2023
Climate change: World aviation agrees ‘aspirational’ net zero plan

Climate change: World aviation agrees ‘aspirational’ net zero plan

October 8, 2022

A newly discovered indentation on the surface of viruses that cause many illnesses, including the common cold, could be their Achilles heel — and a possible target for effective drugs.

When scientists tested antiviral compounds on cells grown in the lab, the team found one that blocked the replication of an enterovirus. Cryo-electron microscopy revealed that the compound binds to and appears to jam a previously unknown pocket on the viruss protein shell, researchers report online June 11 in PLOS Biology.

Additional testing suggests that the pocket is widespread among picornaviruses, the viral family that includes enteroviruses — which cause hand, foot and mouth disease as well as more dangerous infections — and rhinoviruses, responsible for the common cold. There are no antiviral medications available to treat these pathogens.

The pocket “is an excellent target for antivirals” that may be effective against many of these types of viruses, says Susan Hafenstein, a structural virologist with the College of Medicine at Penn State who was not involved in the study.

These viruses mutate very frequently, which makes it “easier for them to escape a drug,” she says. To identify drug targets in the viruses, “it is essential to identify key working components” that these pathogens need to survive.

During an infection, viruses inject their genetic material into cells and take over the cellular machinery to make more viral particles. In picornaviruses, a protein shell surrounds the viruss inner core of genetic material. Previous research suggests the shell changes shape when these viruses are ready to expel their genetic payload during an infection.

But a chemical compound, identified by structural virologist Sarah Butcher of the University of Helsinki, virologist Johan Neyts of the University of Leuven in Belgium andRead More – Source

science news

Previous Post

Private Border Wall Ordered To Keep Its Gate Open

Next Post

Carlton fan cops warning as AFL tells fans: ‘Barrack as loud as you can’

Next Post
Carlton fan cops warning as AFL tells fans: ‘Barrack as loud as you can’

Carlton fan cops warning as AFL tells fans: ‘Barrack as loud as you can’

RECOMMENDED NEWS

CHANGING PLACES LATAM: Blanca García, Juan Manuel Hoyos, Marcel Garreaud…

CHANGING PLACES LATAM: Blanca García, Juan Manuel Hoyos, Marcel Garreaud…

8 years ago
Marine Le Pen uninvited from Web Summit

Marine Le Pen uninvited from Web Summit

7 years ago
Microsoft accelerates goals for reducing carbon footprint     – CNET

Microsoft accelerates goals for reducing carbon footprint – CNET

6 years ago
$1 million of meth found in suitcases in a Washington forest

$1 million of meth found in suitcases in a Washington forest

6 years ago

FOLLOW US

  • 139 Followers
  • 87.2k Followers
  • 202k Subscribers

BROWSE BY CATEGORIES

  • 1xbet Casino Russia
  • 1xbet Russian Top
  • Africa
  • AI
  • Asia
  • Europe
  • Health
  • latest news
  • Latin America
  • Life Style
  • Mail Order Brides
  • Mostbet
  • Online dating
  • onlyfans
  • Pin Up
  • Pin Up Russia
  • Science
  • Sports
  • Tech
  • Uncategorized
  • USA

BROWSE BY TOPICS

2018 League Bali United Beijing BlackBerry Brazil Broja Budget Travel Bundesliga California Champions League Chelsea China Chopper Bike Coronavirus COVID COVID-19 Crime Doctor Terawan EU France French German Istana Negara Italy Kazakhstan Market Stories Mexico National Exam Nigeria Omicron Pakistan Police protests Qatar Ronaldo Russia Smart Voting Sweden TikTok Trump UK Ukraine US vaccine Visit Bali
No Result
View All Result

Recent Posts

  • AI Girlfriends as Creative Writing Partners
  • OnlyFans Platform Analysis
  • How to Day German Fashion
  • Southeast Continental Capabilities
  • What is a Mail Order Wife?

Categories

  • 1xbet Casino Russia
  • 1xbet Russian Top
  • Africa
  • AI
  • Asia
  • Europe
  • Health
  • latest news
  • Latin America
  • Life Style
  • Mail Order Brides
  • Mostbet
  • Online dating
  • onlyfans
  • Pin Up
  • Pin Up Russia
  • Science
  • Sports
  • Tech
  • Uncategorized
  • USA

Tags

2018 League Bali United Beijing BlackBerry Brazil Broja Budget Travel Bundesliga California Champions League Chelsea China Chopper Bike Coronavirus COVID COVID-19 Crime Doctor Terawan EU France French German Istana Negara Italy Kazakhstan Market Stories Mexico National Exam Nigeria Omicron Pakistan Police protests Qatar Ronaldo Russia Smart Voting Sweden TikTok Trump UK Ukraine US vaccine Visit Bali
Federal Government focuses on “integrated security”
latest news

Federal Government focuses on “integrated security”

by The Editor
June 14, 2023
0

Berlin (dpa) – The Federal Government is responding to the challenges of an increasingly unstable world order by means of a “policy...

Read more

Recent News

  • AI Girlfriends as Creative Writing Partners
  • OnlyFans Platform Analysis
  • How to Day German Fashion

Category

  • 1xbet Casino Russia
  • 1xbet Russian Top
  • Africa
  • AI
  • Asia
  • Europe
  • Health
  • latest news
  • Latin America
  • Life Style
  • Mail Order Brides
  • Mostbet
  • Online dating
  • onlyfans
  • Pin Up
  • Pin Up Russia
  • Science
  • Sports
  • Tech
  • Uncategorized
  • USA

Recent News

AI Girlfriends as Creative Writing Partners

May 30, 2025

OnlyFans Platform Analysis

June 12, 2024
  • About
  • Advertise
  • Careers
  • Contact

© 2025 JNews - Premium WordPress news & magazine theme by Jegtheme.

No Result
View All Result
  • Sports
  • USA
  • Asia
  • Health
  • Life Style
  • Tech
  • Science
  • Latin America
  • Africa
  • Europe

© 2025 JNews - Premium WordPress news & magazine theme by Jegtheme.